Love my Sprinter and I know Zman loves his too. I have the full out passenger window version that I take the seats in and out of depending on what I'm doing. Winter it hauls my kids hockey team and lots of people, summer it hauls bikes in the back and less people. But getting 22-23 MPG all the time is very nice and going about 560 miles on a 26 gallon tank is nice. Plus I can tow too when I need to. Sleep in it occasionally as I'll spring for a hotel and real bed if I'm overnight.
If I were to get a new one, I'd probably look at the Transits, Pro Masters, and Sprinters and compare but would be hard to get me out of a Sprinter. They do have their quirks, but a good sprinter forum can usually answer any problem out there.